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ORLISTAT (Xenical, Alli) / Liraglutide (Saxenda)

Orlistat vs. Liraglutide

 

1.Orlistat (Xenical, Alli)

   Function: Orlistat works by blocking the absorption of fat in the digestive system, leading to reduced calorie intake and weight loss

Orlistat is available in two forms – Xenical, which is a prescription-strength dose, and Alli, which is an over-the-counter version with a lower dosage. Xenical is typically recommended for individuals with a BMI over 30, while Alli is used for individuals with a BMI over 25.

   Effects Common side effects of Orlistat include oily spotting, gas with discharge, fecal urgency, fatty or oily stools, and stomach pain. It is important to follow a low-fat diet while taking Orlistat to minimize gastrointestinal side effects.

2.Liraglutide (Saxenda)

   Function: Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that works by slowing digestion and reducing appetite, leading to decreased calorie intake and weight loss.

 Liraglutide is administered via injection and is typically prescribed for long-term weight management in adults with obesity or who are overweight and have at least one weight-related condition. It is not available over the counter.

   Effects: Common side effects of Liraglutide include nausea, vomiting, diarrhea, constipation, and low blood sugar. It may also have benefits for cardiovascular health in addition to weight loss.

Key Differences

– Orlistat acts locally in the digestive system to block fat absorption, while Liraglutide works systemically to affect appetite regulation.

– Orlistat is available in both prescription and over-the-counter forms, while Liraglutide is only available by prescription.

– Orlistat may lead to gastrointestinal side effects related to fat malabsorption, while Liraglutide may have more systemic effects on metabolism and appetite control.

Key Similarities

– Both medications are used for weight management and can help with weight loss when combined with a reduced-calorie diet and increased physical activity.

– Both medications have potential side effects that should be monitored by a healthcare provider.

It’s essential to consult with a healthcare professional before starting any weight loss medication to ensure it is appropriate for your individual needs and health condition. They can provide guidance on the most suitable treatment option based on your medical history and weight loss goals.

Skin Care

The Ultimate Pared-Down Skin Care Routine with Only 3 Products

person applying moisturizer to face in front of a bathroom mirror

We include Skin Care products we think are useful for our readers. If you buy through links on this page, we may earn a small commission. Here’s our process

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How we vet brands and Skin Care products

The skin is your body’s largest and most visible organ. No wonder so many people prioritize skin care.

According to Statista, 1.68 million people in the U.S. spent at least $500 on skin care products during the last 3 months of 2020.

But what if experts told you that it doesn’t take a vanity full of pricey products to give your skin exactly what it needs?

“We don’t believe in dumping the kitchen sink at people’s skin,” says Morgana Colombo, MD, FAAD and a co-founder of Skintap. “We believe in using things that are needed and have good active ingredients that have proven efficacy.”

Though those ingredients may vary from person to person, the building-block products remain the same.

Here’s what a pair of dermatologists say everyone needs to care for their skin. They also dished on nice-to-haves and items you can skip.

Whether it’s a tried-and-true skin care regimen, how often you wash your hair, or the cosmetics you’re curious about, beauty is personal.

That’s why we rely on a diverse group of writers, educators, and other experts to share their tips on everything from the way product application varies to the best sheet mask for your individual needs.

We only recommend something we genuinely love, so if you see a shop link to a specific product or brand, know that it’s been thoroughly researched by our team.

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Must-have skin care products

Angelo Landriscina, MD, FAAD, says it’s easy to complicate things with so many products out there. When it comes to skin care, more isn’t always merrier.

You “can actually make your skin worse by using too many products,” he says.

A morning skin care routine is as easy as 1-2-3 (products). Landriscina advises people to apply the following three products in this order in the morning:

  1. cleanser
  2. moisturizer
  3. sunscreen

Landriscina says you can ditch the sunscreen at night and simply reapply cleanser and moisturizer.

Cleanser

Landriscina and Colombo agree that it’s essential to wash your face thoroughly with lukewarm water and a gentle cleanser before applying any other products.

This allows you to start with a clean slate and prevents other products from washing off.

Landriscina suggests keeping it basic and avoiding something that strips the skin. However, figuring out what that means for you may not be an exact science.

“It’s a trial and error thing,” he says.

Plus, what works now may not be best for you in 10 years.

“The right fit may change,” Landriscina says. “As we get older, our skin gets drier.”

He says your best bet is to start with something designed for sensitive skin, as that’s least likely to cause irritation.

If you know your skin type, Colombo suggests opting for something designed for it.

For example, people with oily or acne-prone skin often do best with a foaming cleanser, whereas people with normal or dry skin typically prefer gentle, nonfoaming options.

Colombo suggests Cetaphil Dermacontrol Foaming Cleanser for oily skin and Cerave Hydrating Cleanser for dry skin.

Moisturizer

Landriscina explains that the skin is designed to keep the outside out (dirt, bacteria) and inside in (organs, bones, and joints).

However, it can lose water. That’s where moisturizer comes in.

“Using a good moisturizer repairs skin barrier function and holds in water,” Landriscina says.

Landriscina recommends:

Sunscreen

Though some moisturizers have SPF 15, Landriscina and Colombo say it’s essential to apply sunscreen and reapply it every 2 hours if you’re exposed to the sun.

They recommend a broad-spectrum sunscreen, which blocks both harmful UVA and UVB rays. Look for one that is at least SPF 30.

“UV rays and UV radiation are the primary modifiable risk factor when it comes to skin cancer risk,” Landriscina says. “Using sunscreen every day consistently the correct way is one of the best things you can do to prevent skin cancer.”

Skin cancer is the most common cancer in the United States, according to the American Academy of Dermatology Association (AAD).

Sunscreen should always go on after cleanser and moisturizer. Allow it to dry before applying makeup.

“It has to form an even film over the skin,” Landriscina explains. “Putting skin care products on after it can disrupt it.”

Nice-to-have skin care products

Some products aren’t necessary but having them may give your skin an extra boost. These include:

Antioxidants

Landriscina says that products with antioxidantsTrusted Source can help prevent or reverse skin damage.

Antioxidants include:

Ingredients with these antioxidants include:

  • turmeric
  • green tea
  • pomegranate
  • coffee
  • rosemary
  • calendula

“The primary way UV radiation damages the skin is through a process called free radical formation,” Landriscina said. “Antioxidants can neutralize those free radicals.”

Science aside, Colombo loves how these antioxidant-rich items make the skin look.

“It helps the skin look glowy and [reduces] redness,” she says.

A 2017 studyTrusted Source indicated that topical use of Vitamin C had anti-aging (or as we like to say “pro-aging”) benefits.

Another study from 2015Trusted Source suggested that topical application of products containing Ubiquinone (coQ10) could reduce free radicals.

A 2016 systematic reviewTrusted Source notes that early evidence shows tumeric could have a positive effect on skin health if applied topically or taken orally.

Landriscina says antioxidants are often present in moisturizers, so you may not need an extra product. You can also find them in serums. Colombo recommends Vidaderma Vitamin C serum.

Hydrating serum

Though a quality moisturizer should do the trick, a hydrating serum can be particularly useful for people with dry skin or who live in drier climates.

Landriscina recommends looking for one with hyaluronic acid and glycerin.

“They are humectants and lock in hydration,” Landriscina says.

A 2012 studyTrusted Source suggested that hyaluronic acid could hydrate the skin, but a 2021 studyTrusted Source indicated that these benefits depend on the molecular weight.

The AAD lists glycerin as an ingredient in creams or ointments that can help relieve dry skin.

Retinol or retinoids

Retinols and retinoids can be great for aging skin.

Colombo explains that retinols are available over the counter, whereas retinoids require a prescription from a dermatologist or primary care physician.

A 2016 studyTrusted Source found that topical application of retinoids significantly reduces wrinkles after 12 weeks.

Skin care items you can live without

Landriscina and Colombo believe skin care is about quality, not quantity. Some tools appear more valuable than they actually are.

They recommend steering clear of:

  • Cleansing brushes. They can be harsh on the skin. “Two clean hands are a perfect way to clean the skin,” Landriscina says.
  • One-time use facial masks. “They’re like cloth masks soaked in a hydrating serum,” Landriscina says. He adds that a hydrating serum can be used multiple times, so it’s more budget-friendly and better for the environment to opt for a bottle.
  • Skin oils. “For most people, those don’t moisturize enough and can clog pores and [exacerbate acne],” Colombo says.
For skin conditions

Keeping it simple is the name of the game, but individuals with certain skin conditions, such as acne, may want to take a few extra steps.

Acne

Colombo says people with acne will want to look for specialized cleansers. Ingredients she often recommends to patients with acne include:

  • salicylic acid
  • sulfur
  • alpha-lipoic acid (ALA)

A 2021 reviewTrusted Source indicated salicylic acid could assist in the treatment of mild-to-moderate acne.

A separate 2021 reviewTrusted Source noted salicylic acid likely wasn’t more effective than benzoyl peroxide. It also indicated that topical products containing sulfur at concentrations of 1 percent to 10 percent could aid in acne treatment.

Colombo suggests avoiding oil-rich products, which can worsen breakouts.

Eczema, rosacea, and sensitive skin

Fragrances can irritate eczema, rosacea, and sensitive skin, so Landriscina suggests people with these conditions avoid scented products.

Colombo suggests keeping products as basic as possible without many bells and whistles. She recommends gentle mineral cleansers and moisturizers.

“Chemical ones with acid [like glycolic acid and retinols] cause more irritation,” she adds. “Ceramides help replenish the skin barrier and retain moisture.”

Speak with a dermatologist

Landriscina says people with skin conditions should make it a point to see a dermatologist in person at least once to get customized care and recommendations.

If a person doesn’t have access to a dermatologist, he suggests seeing a primary care physician.

“A lot of them know about common skin conditions like eczema and acne and may be able to help with prescription medications,” he says.

Do a patch test

Landriscina recommends people with skin conditions, particularly individuals prone to irritation and inflammation, test products before using them. To do this, he suggests:

  1. Apply a small amount of the product once per day to a noncosmetically sensitive area, such as behind the ear.
  2. Check to see if you have a reaction.
  3. Repeat for several days.
  4. If your skin doesn’t react after several days of patch testing, it’s probably safe to use the product as intended.
  5. Stop use and speak with a dermatologist if you have reactions.
Takeaway

Skin care doesn’t have to consist of applying numerous products and constantly changing your routine. In fact, dermatologists recommend against that.

It’s best to stick to a few products that really work for you. Consider a gentle cleanser, moisturizer, and sunscreen your basic, nonnegotiable building blocks. Products with antioxidants and hydrating ingredients, like serums, are useful bonuses.

If you have a skin condition like acne or eczema, speak with a dermatologist or primary care physician and test products before use.


Skin care

Beth Ann Mayer is a New York-based freelance writer and content strategist who specializes in health and parenting writing. Her work has been published in Parents, Shape, and Inside Lacrosse. She is a co-founder of digital content agency Lemonseed Creative and is a graduate of Syracuse University. You can connect with her on LinkedIn.

Wegovy and Mounjaro

Wegovy vs. Mounjaro: What You Should Know

 

wegovy-vs-mounjaro

Wegovy (semaglutide) and Mounjaro (tirzepatide) are prescription drugs that may be used for weight loss and management. But only Wegovy has been FDA-approved for this use. Mounjaro is approved to help treat type 2 diabetes.

Both Wegovy and Mounjaro come as a liquid solution given as an injection under the skin.

This article explains the main ways that Wegovy and Mounjaro are alike and different. For more information about these drugs, including details about their uses, see these in-depth articles on Wegovy and Mounjaro.

What are Wegovy and Mounjaro used for?

Both Wegovy and Mounjaro are prescribed along with diet and exercise to help with weight loss.

Wegovy is FDA-approved for chronic (long-term) weight management in certain situations. Specifically, the drug can be used in people with obesity or those who are overweight and have certain weight-related conditions, including high blood pressure.

Mounjaro isn’t approved for these uses, but it can be prescribed off-label for them. (With off-label use, a drug is prescribed for a condition it isn’t approved to treat.) Mounjaro is FDA-approved to help manage blood sugar levels in adults with type 2 diabetes. To learn more about using Mounjaro for weight loss and weight management, see this article.

To learn more about Wegovy or Mounjaro for treating your condition, talk with your doctor.

Do Wegovy and Mounjaro have generic versions?

generic drug contains an exact copy of the active ingredient in a brand-name medication. (An active ingredient is what makes a drug work.) To find out whether Wegovy or Mounjaro is available as a generic, see below.

  • Wegovy:
    • Available as a generic: no
    • Active ingredient: semaglutide
  • Mounjaro:
    • Available as a generic: no
    • Active ingredient: tirzepatide

Wegovy or Mounjaro and children

Wegovy is approved for weight loss and weight management in certain children ages 12 years and older. Mounjaro is not approved for any use in children.

For more information about the use of Wegovy in children, see this article. You can also talk with your child’s doctor.

How do dosage and administration compare for Wegovy and Mounjaro?

Wegovy and Mounjaro are approved to treat different conditions. Wegovy is used for weight loss and weight management in certain people who are overweight. Mounjaro is sometimes used off-label* for this condition, but it’s only approved to help treat type 2 diabetes.

Both medications are given as an injection under the skin of your abdomen or upper thigh. Or a caregiver may inject either drug under the skin of your upper arm. Your doctor will show you or a caregiver how to inject Wegovy or Mounjaro. They’ll also tell you how often to use it.

To learn more about the dosages for all conditions these drugs treat, see the dosage articles for Wegovy and Mounjaro. To learn more about Mounjaro’s dosage for weight loss and management, see the “How to use Mounjaro” section of this article.

With off-label use, a drug is prescribed for a condition it isn’t approved to treat.

What are the side effects of Wegovy and Mounjaro?

If you use Wegovy or Mounjaro, you may experience mild to serious side effects.

For more information about possible side effects, see the side effect articles on Wegovy and Mounjaro.

Mild side effects

Wegovy and Mounjaro may cause mild side effects. The table below lists examples of mild side effects that have been reported with these drugs.

Wegovy Mounjaro
digestive side effects, such as diarrhea, nausea, constipation, and indigestion (upset stomach)
dizziness
fatigue (low energy)
hair loss
headache
stomach flu
the common cold
injection site reactions, such as swelling and itching around the injection area
mild increases in heart rate

This table may not include all mild side effects of these medications. For more information on mild side effects of the two drugs, see the Wegovy prescribing information and Mounjaro prescribing information.

Serious side effects

In addition to the mild side effects described above, serious side effects may occur in people using Wegovy or Mounjaro. See the table below for a list of serious side effects that have been reported with these drugs.

Wegovy Mounjaro
hypoglycemia (low blood sugar)
pancreatitis (swelling of the pancreas)
cholecystitis (swelling of the gallbladder) and gallstones
severe digestive problems, such as severe diarrhea, which may lead to dehydration or kidney problems
risk of thyroid cancer*
allergic reaction

For more information about possible side effects, see these side effect articles on Wegovy and Mounjaro.

To learn about your specific risk for serious side effects from Wegovy or Mounjaro, talk with your doctor or pharmacist.

Wegovy and Mounjaro have a boxed warningTrusted Source for this side effect. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). To learn more, see the “What are the warnings of Wegovy and Mounjaro?” section below.

How effective are Wegovy and Mounjaro?

You may wonder whether Wegovy or Mounjaro are effective for your condition.

Wegovy is used for weight loss and weight management in certain people with obesity or overweight. Mounjaro is sometimes used off-label for these conditions. (With off-label use, a drug is prescribed for a condition it isn’t approved to treat.) But Mounjaro is only FDA-approved to help manage blood sugar levels in adults with type 2 diabetes.

Studies of Wegovy and Mounjaro have shown that both drugs are effective for their approved uses. Also, studiesTrusted Source looking at Mounjaro for managing type 2 diabetes have shown that the drug leads to weight loss. But it’s important to note that your results from Wegovy or Mounjaro may differ from those seen in studies. Talk with your doctor about whether one of these drugs is right for you.

If you’d like to read more about how each drug performed in studies, see the prescribing information for Wegovy and Mounjaro. And to learn more about using Mounjaro for weight loss and weight management, see this article.

What do Wegovy and Mounjaro cost?

Whether you have health insurance or not, cost may be a factor when you’re considering these drugs. Visit Optum Perks* to get price estimates for Wegovy and Mounjaro when you use coupons from the site. It’s important to note that Optum Perks coupons cannot be used with any insurance copays or benefits.

Keep in mind that what you’ll pay for either drug will depend on your treatment plan, health insurance coverage, and the pharmacy you use.

Wegovy and Mounjaro are both brand-name drugs. These drugs do not have generic forms. You’ll usually pay more for brand-name drugs than for generics.

For other resources that might help you save on the price of these drugs, see the cost articles for Wegovy and Mounjaro.

 Optum Perks is a sister site of Healthline.

mounjaro vs wegovy

What are the warnings for Wegovy and Mounjaro?

Wegovy and Mounjaro may not be right for you if you have certain medical conditions or other factors that affect your health. These may be referred to as warnings.

The two drugs share some of the same warnings, but they also have different ones. Some of these warnings are mentioned below. Before you start using Wegovy or Mounjaro, be sure to talk with your doctor to see if these warnings apply to you.

Boxed warning: Risk of thyroid cancer

Wegovy and Mounjaro both have a boxed warningTrusted Source. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). It alerts doctors and patients about drug effects that may be dangerous.

Risk of thyroid cancer. Animal studies have shown that using semaglutide (the active ingredient in Wegovy) or tirzepatide (the active ingredient in Mounjaro) caused thyroid cancer in mice and rats. (An active ingredient is what makes the drug work.)

Keep in mind that animal studies don’t always predict what happens with humans. It isn’t known for certain whether Wegovy or Mounjaro increases the risk of thyroid cancer in humans. But due to the risk, doctors usually won’t prescribe Wegovy or Mounjaro for certain people, including those with either:

  • multiple endocrine neoplasia type 2 (MEN2), which is a rare genetic (inherited) condition that raises the risk of thyroid cancer
  • a personal or family history of medullary thyroid cancer, which is a rare type of thyroid cancer

Symptoms of thyroid cancer include:

  • hoarse voice
  • lump in your neck
  • trouble swallowing

If you have symptoms of thyroid cancer during treatment with Wegovy or Mounjaro, tell your doctor right away. They may order tests to check for thyroid cancer.

For more information about this warning, talk with your doctor.

Other warnings

In addition to boxed warnings, Wegovy and Mounjaro have other warnings.

Before using Wegovy or Mounjaro, talk with your doctor if any of the following conditions or health factors apply to you.

  • Warnings for Wegovy:
    • if you have depression or suicidal thoughts
  • Warnings for Mounjaro:
    • if you have a severe stomach problem, such as gastroparesis
  • Warnings for both Wegovy and Mounjaro:
    • if you’ve had an allergic reaction to either drug or any of its ingredients
    • if you’re pregnant or planning to become pregnant
    • if you’re breastfeeding or planning to breastfeed
    • if you have a kidney problem
    • if you have a pancreas problem
    • if you have diabetic retinopathy

To learn more about these drugs, see these in-depth articles on Wegovy and Mounjaro.

Help is out there

If you or someone you know is in crisis and considering suicide or self-harm, please seek support:

  • Call or text the 988 Suicide and Crisis Lifeline at 988.
  • Text HOME to the Crisis Text Line at 741741.
  • Not in the United States? Find a helpline in your country with Befrienders Worldwide.
  • Call 911 or your local emergency services number if you feel safe to do so.

If you’re calling on behalf of someone else, stay with them until help arrives. You may remove weapons or substances that can cause harm if you can do so safely.

If you are not in the same household, stay on the phone with them until help arrives.

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Can I switch between Wegovy and Mounjaro?

The short answer: It’s possible, if your doctor recommends it.

Details: Both Wegovy and Mounjaro are prescribed along with diet and exercise to help with weight loss and weight management. It may be possible to switch between the two drugs for these purposes. Your doctor can tell you more.

Reminder: You shouldn’t switch drugs or stop your current treatment unless your doctor recommends it.

What should I ask my doctor?

Wegovy and Mounjaro have different approved uses. Wegovy is used for weight loss and management, while Mounjaro can be used off-label for this purpose.

If you have questions about these drugs, talk with your doctor or pharmacist. They can tell you whether Wegovy or Mounjaro is right for you. Examples of questions you may want to ask include:

  • Do I have a higher risk of hypoglycemia (low blood sugar) with either Wegovy or Mounjaro?
  • How do Wegovy and Mounjaro compare with other treatments for weight loss and weight management?
  • Do any of my health conditions make Wegovy or Mounjaro less safe for me?
  • What diet changes and exercise goals do you recommend for me while using Wegovy or Mounjaro?

To learn more about Wegovy, see these articles:

  • All About Wegovy
  • Side Effects of Wegovy: What You Need to Know
  • Wegovy: How It’s Used for Weight Loss
  • Dosage Details for Wegovy
  • Wegovy and Cost: What You Need to Know

To learn more about Mounjaro, see these articles:

  • All About Mounjaro
  • Side Effects of Mounjaro: What You Need to Know
  • Mounjaro for Weight Loss
  • Mounjaro Interactions: Alcohol, Medications, and Others
  • Dosage for Mounjaro: What You Need to Know
  • Mounjaro and Cost: What You Need to Know

To get information on different conditions and tips for improving your health, subscribe to any of Healthline’s newsletters. You may also want to check out the online communities at Bezzy. It’s a place where people with certain conditions can find support and connect with others.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Dysport and Botox

What’s the Difference Between Botox and Dysport?

Dysport and Botox are nonsurgical forms of wrinkle treatment. Dysport is only approved for glabellar lines, or the area between your eyebrows. Botox is approved for treating forehead lines and fine lines around the eyes (crow’s feet), in addition to glabellar lines.

 

Dysport and Botox are commonly used to reduce the appearance of fine lines and wrinkles on the face and forehead. While they both have medical uses, they’re most popular as injectable cosmetic treatments.

Both are types of neurotoxins that block muscle contractions. Derived from botulinum toxin, they are safe to use in small amounts.

Dysport and Botox are both considered nonsurgical forms of wrinkle treatment that have quick recovery rates. While they have many similarities, there are some differences between the two treatments.

Keep reading to learn more about Dysport and Botox.

Dysport and Botox injections temporarily reduce the appearance of wrinkles by relaxing the underlying muscles beneath the skin. By relaxing the muscles, the skin on top becomes smoother.

 

 

Both treatments contain a similar main ingredient, but the trace protein amounts they contain vary. This may make one treatment more effective than the other for some people. Their exact differences are being studied.

Both Dysport and Botox injections only take a few minutes to administer. The longest part of each procedure is the application and drying of the anesthetic, rather than the injections themselves.

Unless you develop immediate side effects, you’ll be able to leave shortly after your appointment.

What is Dysport?

Dysport reduces the appearance of lines that affect the glabella, the area between your eyebrows. These lines extend upward between the eyebrows toward the forehead. Glabella lines are especially noticeable when you frown or squint. Over time, glabella lines can become more prominent during times of relaxation, too.

Dysport is meant for use in people with moderate to severe glabella lines, not mild lines. Your dermatologist or plastic surgeon can help you tell the difference between mild and moderate wrinkles of this type.

If you’re a candidate for Dysport, the entire procedure is done at your doctor’s office.

Before the injections, your doctor will apply a mild anesthetic to help alleviate any pain felt during the procedure.

For the treatment of frown lines, doctors typically inject 0.05 milliliters (mL) at a time in up to five portions around your eyebrows and forehead.

Dysport

 

What is Botox?

Botox is FDA approved for treating forehead lines and fine lines around the eyes (crow’s feet), in addition to glabellar lines. This differs from Dysport, which is only approved for glabellar lines.

The procedure involving Botox is like that of Dysport. The procedure is done at your doctor’s office with minimal recovery time.

 

botox

The number of units your doctor will use depends on the area being treated and your desired results. The recommended average Botox dosages by treatment area are as follows:

  • Glabellar lines: 20 total units, 5 injection sites
  • Glabellar and forehead lines: 40 total units, 10 injection sites
  • Crow’s feet: 24 total units, 6 injection sites
  • All three types of wrinkles combined: 64 units
Dysport vs. Botox chart

Dysport and Botox share many similarities, but one of these treatments might be a better fit for you over the other. Consider some similarities and differences below:

Dysport Botox
Procedure type nonsurgical nonsurgical
What it treats glabellar lines
  • glabellar lines
  • forehead lines
  • crow’s feet around the eyes
Cost average cost $400 per session. average cost $300–$600 per session
Pain no pain is felt during the procedure, but slight pain may be felt at injection site after treatment treatment doesn’t cause pain, but slight numbness and pain may be felt after the procedure
Number of treatments needed each session is about an hour long, and follow-ups are every few months to maintain desired results same as Dysport, except sometimes Botox can wear off sooner in some people
Expected results results within a couple of days, lasting between 3 and 4 months at a time results in 1 week to 1 month, lasting a few months at a time
Who should avoid treatment?
  • people who have milk allergies
  • people taking certain medications for muscle spasms
  • people who are pregnant
  • people taking certain medications for muscle spasms
  • people who are pregnant
Procedure and recovery time procedure less than 20 minutes with little to no recovery time needed procedure less than 20 minutes with little to no recovery time needed
Which is more effective?

Unlike traditional surgical procedures, you’ll see the results from these cosmetic injections within a few days of treatment. Neither Dysport nor Botox require recovery time. You can go home right after the procedure is finished.

Dysport results

Dysport can start taking effect after a couple of days. Results can last up to 5 months. You’ll need to go back for more injections to maintain treatment effects.

Botox results

You may start seeing results from Botox within a week, but full results can take up to 1 month. Botox injections also last a few months at a time, with some lasting upward of 6 months.

Who’s a good candidate for Dysport and Botox?

Both Dysport and Botox injections are intended for healthy adults, 18 or over, with moderate to severe facial lines. Your doctor will review your medical history and ask you some questions to determine if you’re a good candidate.

As a rule of thumb, you may not be a candidate for either procedure if you:

  • are pregnant
  • have a history of botulinum toxin sensitivity
  • have a milk allergy
  • have a skin disorder
  • have thick skin (as determined by your doctor)
  • are over 65 years old
  • take certain medications

Several medications may interact with the ingredients in the injections. These include blood thinners and muscle relaxers.

The injections may also interact with certain medications that affect your muscles, such as anticholinergicsused forParkinson’s disease.

Check with your doctor before discontinuing use of any current medication you’re taking. It’s also important to tell your doctor about all the medications and supplements you take, even if they’re over the counter.

What are the side effects?

Although severe side effects of Dysport or Botox are rare, minor side effects are possible. Usually, these side effects resolve on their own without further issue.

Talk with your doctor about all possible side effects and risks before you get any treatment, so you know what to expect.

Side effects of Dysport

Dysport is considered an overall safe treatment, but minor side effects include:

  • minor pain at injection site
  • swelling around the eyelids
  • rash and irritation
  • headaches

These side effects typically resolve after a few days.

More serious side effects may include nausea, sinusitis, and upper respiratory infection. Call your doctor if you develop any of these side effects or if you have other side effects that worsen or persist.

Side effects of Botox

Like Dysport, Botox is considered safe and has minimal side effects. Some of the most common side effects post-treatment include:

  • redness
  • swelling
  • bruising
  • slight pain
  • numbness
  • headache

Minor side effects usually resolve within a week of the procedure, according to the American Academy of Dermatology.

While extremely rare, both Dysport and Botox can cause botulinum toxicity, a serious complication. Botulinum toxicity occurs when the injection spreads to another part of the body. Seek emergency medical treatment if you suspect botulinum toxicity from your treatments.

Signs of botulinum toxicity include:

  • droopy eyelids
  • facial muscle weakness
  • muscle spasms
  • difficulty swallowing and eating
  • breathing difficulties
  • difficulty with speech
How to find a professional

No matter which type of injection you choose, it’s important to select the right professional to administer it. Many board certified dermatologists and plastic surgeons administer Botox and Dysport at their offices, and are approved at some medi-spas.

Always check that the professional you choose will be the one to administer the injections. Never see a non-medical provider or anyone who is unwilling to show you their clinical license.

Don’t be shy about asking your provider about their experience with Dysport and Botox. Many professionals will also suggest scheduling a consultation. At that time, they can discuss which procedure might be best for you.

To find a dermatologic surgeon, consider searching location-based databases from the American Society for Dermatologic Surgery or the American Society of Plastic Surgeons as a starting point.

Clinical applications of Dysport and Botox

In addition to treating wrinkles, Botox can be used to treat conditions, such as:

Dysport can be used as a clinical treatment for:

  • cervical dystonia (abnormal head position and neck pain)
  • spasticity not caused by cerebral palsy (muscle spasms and stiffness in arms, hands, legs, and feet)
Takeaway

Botox and Dysport are injectable medications used to treat facial wrinkles and other conditions. Both brands are made from similar forms of botulinum toxin.

Dysport is meant for use on the vertical lines that form between the eyebrows (glabellar lines). Botox is meant for use on glabellar lines, forehead lines, and crow’s feet (laugh lines) around the eyes.

Botox and Dysport are considered safe for most people, but it’s important to talk with a qualified medical specialist before you get either treatment. If you’re interested in these treatments, schedule a consultation with a qualified dermatologist.

Mounjaro for Weight Loss: Does it Work?

Mounjaro for Weight Loss: Does it Work?

A comprehensive guide to using Mounjaro for weight loss

New weight loss medications make headlines every few months. Mounjaro, manufactured by Eli Lilly, is gaining steam based on its remarkable efficacy in helping patients lose weight. Although the drug is not FDA-approved for weight loss, healthcare providers are increasingly prescribing Mounjaro and drugs like it to help patients achieve and maintain a healthy weight. This article will examine how effective Mounjaro is as a weight loss drug, how it works, and what to consider before taking it.

What is Mounjaro?

Mounjaro is a prescription medication manufactured by drugmaker Eli Lilly. The U.S. Food and Drug Administration has approved Mounjaro for use in American markets as a treatment for type 2 diabetes. It is supplied as an injectable pen that should be used once a week. Mounjaro is only available under its brand name (Mounjaro). It does not come in a generic version.

Mounjaro contains the active ingredient tirzepatide, which belongs to a novel class of drugs called dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonists.

When blood sugar levels rise rapidly after consuming sugary or high-carbohydrate foods, it can lead to a surge in insulin production. This release can quickly drop blood sugar levels, triggering feelings of hunger and increased appetite shortly after eating. Blood sugar spikes can lead to overeating as the body tries to regulate blood sugar levels. You may feel the need to eat more to maintain stable blood sugar, which can contribute to consuming excess calories and weight gain over time. Frequent blood sugar spikes can also lead to cravings for more sugary or carbohydrate-rich foods, creating a cycle of unhealthy eating habits.

The dual action of Mounjaro targets blood sugar levels in multiple ways.

Mounjaro’s mechanisms of action include:

  • Prompting the pancreas to release insulin when blood sugar levels are high (known as the glucose-dependent insulin response)
  • Decreasing the release of glucagon, which aids in lowering blood sugar levels
  • Slowing the process of stomach emptying, aiding in appetite control, and reducing food consumption
  • Encouraging a feeling of fullness following meals

In sum, Mounjaro helps patients managing type 2 diabetes regulate their blood sugar levels (especially after meals) while also preventing an increased appetite and craving for sugary or high-carbohydrate food after eating.

How does Mounjaro work for weight loss?

The diabetes drug Mounjaro differentiates itself from other treatment options (like Novo Nordisk’s Ozempic or Wegovy) through its dual action. Whereas semaglutide—the active ingredient in Ozempic—only replicates the action of GLP-1 in the body, Moujaro replicates GLP-1 and GIP, which yields a more potent effect on blood sugar levels and weight management.

GLP-1 drugs are medications prescribed by doctors to help people with type 2 diabetes control their blood sugar levels. They mimic the actions of a natural hormone called GLP-1, which your body releases when you eat. When you have a meal, your body releases GLP-1, which tells your pancreas to make more insulin. Insulin is a hormone that helps lower the amount of sugar in your blood. It allows the sugar in your blood to enter your cells, which can be used for energy or stored for later. GLP-1 helps ensure that insulin is released at the correct times, like after a meal when your blood sugar goes up.

GLP-1 also does a few other helpful things. It reduces the release of another hormone called glucagon, which comes from the pancreas, too. Glucagon does the opposite of insulin; it raises blood sugar levels by telling your liver to release stored sugar into your blood. By blocking glucagon’s action, GLP-1 helps prevent too much sugar from being released by the liver, which can lead to high blood sugar levels.

Furthermore, GLP-1 slows down your stomach emptying, making you feel full for longer after eating. It does this by directly affecting your stomach, causing it to take more time to pass food into the small intestine. This slower digestion means that the nutrients from your meal are released into your body more gradually.

GLP-1 also affects your brain, making you feel more satisfied and less hungry. When GLP-1 is released after you eat, it signals to your brain that your stomach is full, so you don’t feel the need to eat more. This helps reduce your appetite.

Stabilized blood sugar levels and a reduced appetite have been shown to help patients managing type 2 diabetes also lose weight—when coupled with a reduced-calorie diet and increased physical activity.

GIP

The glucose-dependent insulinotropic polypeptide (GIP) is a hormone your gut releases when you eat. Its primary role is to help control your blood sugar levels in response to the food you consume after a meal, especially one containing carbohydrates and fats.

This hormone then signals your pancreas to release insulin, which helps your cells absorb and utilize the sugar from the food you’ve eaten, and it also prevents your liver from producing too much sugar.

While GIP’s role in weight loss is still being studied, its role in promoting insulin release and improving glucose uptake may indirectly support weight loss by helping to regulate blood sugar levels. Stable blood sugar levels can reduce cravings for sugary and high-calorie foods.

Is Mounjaro Safe?

Mounjaro has been approved by the FDA as a supplement to diet and exercise to improve blood sugar regulation in patients with type 2 diabetes. This approval was based on the results of various clinical trials comparing Mounjaro to other diabetes treatments. Participants in these trials experienced significant reductions in their A1C levels, ranging from 1.7% to 2.4% for different dosages of Mounjaro, and also achieved weight loss between 12 lbs. to 25 lbs. on average.

While Mounjaro is safe and effective for most adults managing type 2 diabetes, it has been shown to cause side effects in some patients.

The most common side effects of Mounjaro include gastrointestinal issues like constipation, diarrhea, stomach discomfort, and gas.

Less common but more severe side effects may include allergic reactions, low blood sugar (hypoglycemia), as well as an increased risk of thyroid cancer, gallbladder disease, and acute pancreatitis.

In addition, Mounjaro may not be safe for certain individuals with previously diagnosed medical conditions.

Your healthcare provider may not prescribe Mounjaro if you meet one of the following criteria:

  • You have a history of thyroid, pancreatic, gallbladder, or kidney issues
  • You are under 18 years of age
  • You have type 1 diabetes
  • You have diabetic retinopathy
  • You have a history of stomach or digestive problems

Mounjaro may not be prescribed to pregnant women, women who are trying to conceive, or women who are breastfeeding.

Before starting treatment with any prescription medication, you should tell your doctor about any medical conditions you have, any medications or supplements you are taking, and any allergies you may have. This information will help reduce the risk of any possible interactions or adverse reactions to Mounjaro.

Who should take Mounjaro for weight loss?

Moujaro is FDA-approved to regulate blood sugar levels in patients managing type 2 diabetes. Its use as a weight loss aid is off-label, meaning that weight loss is not the primary use of this drug. However, because 90% of adults with type 2 diabetes also have obesity or are overweight, the several benefits of Mounjaro affect both comorbidities.

Mounjaro may be prescribed to individuals with or without type 2 diabetes. When prescribed as a weight loss aid, it is specifically indicated for use in adults with obesity (with a body mass index— BMI—of 30 kg/m2 or greater) or overweight adults (a BMI of 27 kg/m2 or greater) who also have weight-related medical problems such as high blood pressure, heart disease, or obstructive sleep apnea.

In general, higher doses of tirzepatide—the active ingredient in Mounjaro—are shown to produce more significant effects on body weight. Mounjaro is usually supplied as a 2.5 mg dose for the first four weeks. After these four weeks, the dosage may increase to 5 mg per week, depending on the patient’s tolerance for the medication and the efficacy of treatment.

Talk to your healthcare provider about whether or not Mounjaro is right for you and your condition.

Is There An Alternative to Mounjaro?

There are several drugs used for the treatment of obesity on the market. As of November 12th, the FDA has approved Eli Lilly and Company’s Zepbound (tirzepatide) injection specifically for this use (as opposed to the off-label use of Mounjaro).

Zepbound’s approval was based on clinical trials in which adults with obesity experienced significant weight loss when taking weekly injections of Zepbound in combination with diet and exercise. The highest dose of Zepbound resulted in an average weight loss of 48 pounds over 72 weeks, while the lowest dose led to an average loss of 34 pounds, compared to only 7 pounds in the placebo group. Moreover, 1 in 3 patients on the highest dose lost over 58 pounds.

The weight loss effected by Zepbound and adjunct lifestyle changes coincided with reduced cholesterol levels, blood pressure, and waist size.

Zepbound is not currently available, but will be soon. Talk to your healthcare provider about Zepbound and when it might become available for prescription.

How do I get a prescription for Mounjaro?

Mounjaro is a prescription drug, meaning that you must have a written order from a licensed healthcare provider to get it. There is no generic version of this drug, nor can you buy Mounjaro over the counter.

Weight loss drugs are prescribed to individuals with obesity or individuals who are overweight and managing a weight-related health condition. If you are curious about Mounjaro or any other weight loss drug, talk to your healthcare provider about whether or not these treatment options are right for you. You should also discuss the cost, potential side effects, and any concerns you may have.

Can I get Mounjaro on Sesame?

Sesame offers a comprehensive online weight loss program to help you get started on your weight loss journey.

Sesame’s online weight loss program is a subscription which renews every 3 months and includes a video consultation with a weight loss doctor or specialist, a GLP-1 prescription (if appropriate), insurance coordination for medication coverage, and 90 days of unlimited messaging with your provider.

Note that all prescriptions are at the discretion of your healthcare provider.

Sources

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